Switchies waltzers3/5/2023 ![]() ![]() This research was supported by the Dyson Bequest, the DHB Foundation, the Australian National Health and Medical Research Council, the Victorian State Government and a Bellberry-Viertel Senior Medical Research fellowship. ![]() The next steps for the research will investigate why the accordion effect is required for gene silencing and the relevance of the process for genes on other chromosomes, such as the autosomes. The study uncovered a new molecular mechanism of gene silencing, with the researchers pinpointing the protein complex required for this process, known as the BAF complex. The system reported gene activity from each X chromosome through the expression of a red and green fluorescent protein, to reveal if the gene silencing process was occurring normally. To enable this, the team created a system they called 'Xmas', based on red and green tags that are normally switched off during development. The fundamental mechanistic study was focused on efficiently searching for new factors involved in the gene silencing process. "To be able to realise this dream, we first need to know how the process happens so it can be mimicked with medicines, and our discovery is one more vital piece of this puzzle." "If you could switch off the oncogenes that drive cancer, for example, you potentially could have a new treatment. "If we could learn exactly how to switch genes off, we may one day be able to switch off detrimental genes in a variety of diseases," Dr Keniry said.
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